Anxiety and Anxiolytics Sum 2007

Anxiety and Anxiolytics Sum 2007 - LeDoux/Davis Model of...

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Anxiety and Anxiolytics Summer 2007
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Three Major Classes of Anxiolytic Drugs Alcohol Barbiturates Benzodiazepines
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Dose-Response Effects of Anxiolytic Drugs Low Dose: Anxiolysis Moderate Dose: Behavioral disinhibition Moderate-High Dose: Sedation High Dose: Hypnosis Highest Dose: General anesthesia (unconsciousness)
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Is There a Brain System For Anxiety?
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Some Methods Used to Investigate Fear and Anxiety in Rats Pavlovian Fear Conditioning: measure the rat’s freezing response to a tone previously paired with footshock (major method of LeDoux) Fear Potentiated Startle: measure the augmentation of the startle response to a loud noise by a light previously paired with footshock (major method of Davis) Elevated Plus Maze Social anxiety test
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Fear-Potentiated Startle in Rats
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The amygdala in the rat brain Lateral Amygdala Basolateral Amygdala Central Nucleus Of Amygdala
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Davis: Lesion of Basolateral Amygdala Prevents Fear-Potentiated Startle
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Unformatted text preview: LeDoux/Davis Model of Fear Conditioning LTP as the model for fear conditioning in the amygdala Frodl et al. (2002): Greater Amygdala Volume in Depressed People Stimuli used in Hariri, et al., 2002 study of amygdala response to fearful faces Amygdala fMRI response to fearful faces for different 5HT transporter gene polymorphisms Other Approaches to the Neurochemistry of Anxiety Corticotropin Releasing Factor (CRF) Maier and Watkins: caudal dorsal raphe Panicolytic drugs PANIC ! Anxiety induced by caffeine varies with adenosine receptor gene polymorphism Doxapram, which induces hyperventilation, enhances fear conditioning in rats Doxapram reduces social interaction in rats Doxapram induces fos activation in central nucleus of the amygdala Decreased escape attempts in unstable elevated exposed plus-maze after 21 days fluoxetine...
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Anxiety and Anxiolytics Sum 2007 - LeDoux/Davis Model of...

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