Intro Neurodegenerative Disorders- iMCP2 - W2020 post.pptx - Integrated Medicinal Chemistry Pharmacology II PSC 6311 Neurodegenerative Disorders

Intro Neurodegenerative Disorders- iMCP2 - W2020 post.pptx...

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Integrated Medicinal Chemistry & Pharmacology II PSC 6311Neurodegenerative Disorders: IntroductionChap 18: Goodman & Gilman’s The Pharmacological Basis of Therapeutics, 13thed. Chap 28: Basic and Clinical Pharmacology, Katzung, 14thed. Chap 13: Foye’s Principles of Medicinal Chemistry, 7thed.Karen Mark, PhD; Associate ProfessorPharmaceutical SciencesRm 275 Ph: 865-288-5839 Email:
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Lecture Objectives1.Explain selective neurodegeneration, processes that contribute to neuronal loss, and related implications 2.List the different types of neurodegenerative diseases and indicate the target problem that underlies the diseases presentation and potential treatment 3.Compare and contrast neurodegenerative diseases as they related to neuronal mechanisms; including potential biological targets for symptomatic / disease therapy 4.Describe any drug(s) that are used for symptomatic treatment of neurodegenerative disease including the MOA and key side effects. 5.Identify when a drug used for one neurodegenerative disease is contraindicated for another
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Neurodegenerative Disorders Characterized by progressive and irreversible loss of neurons from specific regions of the brain / spinal cordSpecific neurons (type / location) affected in each neurodegenerative disease Neurophysiological result from neurodegeneration Neurodegeneration in basal ganglia  abnormal motor control signaling from thalamus to cerebral cortex Impairment of cortical or hippocampal neurons   memory and cognitive decline Pathogenic factors and/or processes associated with neurodegenerative disorders Risk factors – gender, diet, environment, lifestyle Genetic mutations Currently only symptomatic treatments availableResearch is focused on biological targets to treating the various diseases
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Neurodegenerative DiseasesIn neurodegenerative diseases such as AD, PD, HD, and ALS; specific typesof neurons die Symptoms depends on function of these specific neurons and where in brain they are affectedReasons for selective vulnerabilityare unknown but include:Protein aggregates (beta-amyloid for AD)Toxic peptides
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