Chem120A+Notes+-+Komvopoulos+Biointerface+Modification

Chem120A+Notes+-+Komvopoulos+Biointerface+Modification -...

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Unformatted text preview: Professor K. Komvopoulos, Director Professor K. Komvopoulos, Director Surface Sciences and Engineering Laboratory (SSEL) Surface Sciences and Engineering Laboratory (SSEL) Computational Surface Mechanics Laboratory (CSML) Computational Surface Mechanics Laboratory (CSML) Department of Mechanical Engineering Department of Mechanical Engineering University of California, Berkeley, CA 94720 University of California, Berkeley, CA 94720 Chemistry 120A Chemistry 120A , Lecture, 12/1/2008 , Lecture, 12/1/2008 Biosurface Biosurface Chemical Modification for Controlled Chemical Modification for Controlled Cell Adhesion and Proliferation Cell Adhesion and Proliferation BIOMATERIAL BIOMATERIAL Any material, either a simple member of a class of materials or a combination of two or more members of the same or different classes, with the following characteristics: can be used in a living organism for a certain implant or a group of implants, does not cause negative reactions from the organism, and is stable and biodegradable in a controlled way. INTRODUCTION INTRODUCTION 1945: F 1945: F irst irst successful dialysis treatment successful dialysis treatment Willem Kolff Kolff rotating drum kidney (1943) 1955 1955 : Gibbons heart lung machine : Gibbons heart lung machine John H. Gibbon, Mary H. Gibbon and heart-lung machine, u.d. (Art/Photo Collection, AG-054) Biomaterial Applications Biomaterial Applications Biomaterial Biomaterial Application Application s s (contd) (contd) Artificial bone (knee and hip joints) Artificial organs (kidney, liver, pancreas,) Stents, catheters, blood bags,... Artificial bone Artificial kidney Stent Parameters Parameters Affecting Bio Affecting Bio compatibility compatibility Physicochemical properties of the material Biological environment, functional conditions Manufacturing process of the implant or the artificial organ Approval of Approval of B B iomaterials iomaterials International/National regulations (ISO, FDA, NIH, ASTM,..) Handbooks with instructions (from literature or as a result of committees, conferences ) Classic code: ISO 10993 Artificial metals alloys ceramics polymers Composites Biological collagen liposomes hydrogels Stable (permanent use) (bioinert) Biodegradable (controlled) (bioresorbable) Bioactive Characteristics of Biomaterials Characteristics of Biomaterials Types Types Important characteristics Important characteristics Problems and Need for Chemical Problems and Need for Chemical Treatment of Biosurfaces Treatment of Biosurfaces Problem Problem : Blood contact and thrombosis Blood contact and thrombosis peacemakers peacemakers vascular grafts vascular grafts heart valve heart valve catheters for intravenous procedures catheters for intravenous procedures Thromboembolism Thromboembolism Thrombus Thrombus Embolism Embolism Hemocompatibility Hemocompatibility Resist clot formation...
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This note was uploaded on 09/28/2009 for the course CHEM 120A taught by Professor Whaley during the Spring '07 term at University of California, Berkeley.

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Chem120A+Notes+-+Komvopoulos+Biointerface+Modification -...

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