09.02 - 10 mM Vm=-60 mV E K =-68 mV K K 140 mM 10 mM Vm=-60...

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Neural Membranes gradients, potentials, channels K+ K+ Na+ Na+ anions (-) ( + ) Total Gradients
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K+ K+ Na+ Na+ anions (-) ( + ) Membrane potential K+ Ion Intracellular Extracellular Potassium ( K+ ) 140 5 Sodium ( Na+ ) 12 145 Chloirde ( Cl -) 15 120 Calcium ( Ca++ ) 0.0001 2
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The Nernst Equation The Nernst Equation Selective permeability establishes the membrane potential.
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Establishing Equilibrium Potential Separation of charges creates an electrical gradient This is the membrane potential (Vm) Ions Fow across membrane following the gradient This Fow creates a concentration gradient ±low continues until the electrical gradient “balances” the concentration gradient This Vm is the equilibrium potential for that ion Therefore. .. Either the concentration of the ion establishes the membrane potential Or the membrane potential establishes the relative concentrations of the ion K+ K+ 140 mM
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Unformatted text preview: 10 mM Vm= -60 mV E K = -68 mV K+ K+ 140 mM 10 mM Vm= -60 mV Na+ Na+ 12 mM 145 mM E Na = ? mV K+ K+ 140 mM 10 mM Na+ Na+ 12 mM 145 mM Vm= -60 mV E K = -68 mV E Na = +54 mV Establishing Resting Potential • The ions fow across the membrane Following gradients • They will continue to fow until the equilibrium potential For that ion has been reached • ThereFore, each ion is contributing to the net current across the membrane • The contribution oF each ion is proportional to the rate oF conductance oF that ion. So, the Factors that contribute to the resting potential oF a cell include: Which ions are permeable at rest The equilibrium potential oF these ions The relative permeability oF each ion The Goldman Hodgkin Katz Equation includes permeability and assumes monovalent ions...
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This note was uploaded on 09/28/2009 for the course BIO 365R taught by Professor Draper during the Fall '08 term at University of Texas.

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09.02 - 10 mM Vm=-60 mV E K =-68 mV K K 140 mM 10 mM Vm=-60...

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