Cerebellum_08 - Stellate Cell – Lateral inhibition •...

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Cerebellum
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Functional Parts
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Cerebellum Lobes
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Comparator Cortex
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Cerebellar Inputs
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Cerebellar Cortex Molecular Layer Stellate and Basket Cells, Parallel Fibers, Purkinje Cell dendrites Purkinje Cell Layer Granular Layer 10 11 granule cells, Golgi Cells, Mossy Fibers, Cerebellatr Glomeuli
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Cerebellar Glomeruli
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Cell Types Purkinje Cell 15 million, large, 50μ diameter, receive 200K inputs, sole output of the cerebellum, inhibitory Granule Cell Becomes parallel fibers, small, densely packed, most numerous neuron in the brain, generate simple spikes in Purkinje Cells Basket Cell Lateral inhibition
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Cell Types
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Unformatted text preview: Stellate Cell – Lateral inhibition • Golgi Cell – Interneuron, recurrent inhibition on Mossy Fiber endings Types of Fiber Inputs • Mossy Fibers – Ia, Ib, and other inputs from the cerebral cortex – End in cerebellar glomerulus – One fiber may synapse with 10K granule cells • Climbing Fibers – One for each Purkinje cell, Branch to < 10 PC – Makes 500 synaptic contacts with Purkinje cell – Arise primarily from the Inferior Olive – Generate Prolonged VG Ca ++ complex spikes Microscopic Structure Simple and Complex Spikes Synchronization of Complex Spikes...
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Cerebellum_08 - Stellate Cell – Lateral inhibition •...

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