NeuroPhysIntro09 - Unique membrane signaling properties...

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Neurophysiology The study of the anatomy, physiology, and pharmacology of the nervous system Central Nervous System: Brain and Spinal Cord Peripheral Nervous System: Autonomic and Spinal Nerves
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Brain Who you are (Consciousness) Affect Cognition Motor Sensory Memory Regulates all autonomic functions Changes throughout life
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Human Brain 20 yoa brain 1.5Kg male 1.4Kg female 90 yoa brain 1.2Kg male 1.15 female 2% body weight 20% cardiac output (3 min reserve)
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Brain Born with a full set of cells 10 11 neurons, 10 12 glial cells Number of neural cells decreases throughout life. Fetal brain has 3X as many cells as the adult brain “Use it or loose it” Some neurogenesis in the hippocampus
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Neurogenesis
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Neuroprotection
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Apoptosis
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Excitotoxicity
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Excitotoxicity Induced Apoptosis
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Brain Connectedness changes throughout life Memory, learning, planning, abstract thought are all plastic
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Neurons Like other cells Highly differentiated
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Unformatted text preview: Unique membrane signaling properties Grouped into functional units Motor Sensory Cognition Neurons have many mitochondria Microtubules Goldman Equation C=[Solute] R=Universal Gas Constant T=Temperature (K) Cell Membrane Channel Proteins Water Moves freely between intracellular and extracellular space Osmotic equilibrium Tonicity How a solution affects cell volume Hypotonic Cell Swells Hypertonic Cell Shrinks Cell Membrane Diffusion Oxygen, CO 2 , most lipids diffuse freely Ions, polar molecules, proteins diffuse poorly Size, lipid solubility determine permeability Facilitated Diffusion Requires a membrane protein, no energy Channel Proteins: water, ion channels Carrier Proteins: glucose Glucose: Facilitated Diffusion Na and K: Active Transport Requires external energy and protein carrier...
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NeuroPhysIntro09 - Unique membrane signaling properties...

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