Synapse09 - Electrical Synapse • Bidirectional No...

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Unformatted text preview: Electrical Synapse • Bidirectional, No synaptic delay, Astrocytes, Schwann Cells (CMT Disease) UTHSCH Electrical Synapse • Connexin-gap junction protein • Strength of the synapse can be modulated by PKA • Neuromodulation is local • PKA activation decreased coupling • PKA inhibition increased coupling • Pores are large enough to pass ATP and other intracellular messengers between cells • “Bystander killing” Chemical Synapse • Unidirectional • Excitatory, Inhibitory, Synaptic Delay Ca++ Binding Vesicle Fusion Membrane Retrieval Receptor Specificity The post-synaptic receptor, not the NT, determines the response of the post-synaptic cell Types of Neurotransmitter Receptors Ach Glutamate Serotonin Hormones Growth Factor Asthma Treatment • Beta 2 agonists – Albuterol, Alupent, Advair • Anticholinergics – Atrovent (ipratropium) • Theophylline Acetylcholine is the neurotransmitter at the motor endplate Acetylcholine Receptor Ach Receptor Morphology...
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This note was uploaded on 09/28/2009 for the course BME 365R taught by Professor Rylander during the Fall '09 term at University of Texas.

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Synapse09 - Electrical Synapse • Bidirectional No...

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