325usum08DNAreplTelomere

325usum08DNAreplTelomere - The rest of the semester DNA in...

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The rest of the semester: “DNA in motion” Today: DNA Replication, Telomeres, and Mitosis
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Fig 16.1 Gene Expression is regulated due to environmental and developmental cues: DNA packaging Transcription RNA processing and transport RNA degradation Translation Post-translational
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For life to exist, the information (genes) must be passed on.
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Fig 3.5 The Cell Cycle
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DNA replication precedes cell division
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DNA replication starts at the origin of replication Fig 11.21
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Fig 11.5 Prokaryotic origin of replication
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DNA replication is initiated by the binding of DnaA proteins to the DnaA box sequences This binding stimulates the cooperative binding of an additional 20 to 40 DnaA proteins to form a large complex Other proteins such as HU and IHF also bind. This causes the region to wrap around the DnaA proteins and separates the AT-rich region Fig 11.6
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Composed of six subunits Travels along the DNA in the 5’ to 3’ direction Uses energy from ATP Bidirectional replication Fig 11.6
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DNA replication starts at the origin of replication Helicase unwinds/separates the two strands of DNA. Fig 11.21
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DNA replication starts at the origin of replication The DNA is copied Fig 11.21
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DNA replication starts at the origin of replication The DNA is copied More unwinding, more copying Fig 11.21
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DNA replication starts at the origin of replication The DNA has now been copied. There are now two double-stranded DNAs Fig 11.21
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3' Completely single stranded 5' G A A T C T G C Polymerase inactive 3' 5' Completely double stranded 5' 3' G A A T C T G C C T T A G A C G Polymerase inactive 3' 5' Single strand as template plus 3' end to start synthesis 5' OH 3' G A A T C T G C C T T Polymerase active DNA polymerase can only use some DNA as template Fig 11.9
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Fig 11.7 Primase adds an RNA primer to allow DNA polymerase to begin
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Fig 11.11 DNA polymerase adds nuleotides to the 3’-end
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QuickTimeª and a TIFF (Uncompressed) decompressor are needed to see this picture. Fig 11.10
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TIFF (Uncompressed) decompressor are needed to see this picture. Fig 11.10
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This note was uploaded on 09/28/2009 for the course BIO 325 taught by Professor Saxena during the Summer '08 term at University of Texas.

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325usum08DNAreplTelomere - The rest of the semester DNA in...

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