F08pages33-43

F08pages33-43 - If mutations are in same gene If mutations...

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If mutations are in same gene ye/ye pa/pa ye/pa If mutations are in different linked genes ye pa+ ye pa+ ye+ pa ye+ pa ye pa+ ye+ pa Mutant phenotype Wild type phenotype Question What is the result from the complementation test if ye and pa were mutations in different unlinked genes? Chapter 16 The Molecular Basis of Inheritance Outline of lecture • Discovery of DNA structure. • Base pairs, sugar/phosphate backbone, antiparallel strands. • DNA replication on paper. • Enzymatic DNA replication by DNA polymerases, primase, ligase. Reading Assignment James Watson Francis Crick • 7th edition - All of Chapter 16 • 8th edition - 305 - 319. 33
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Discovery of the Structure of DNA The components of DNA Thymine (T) Adenine (A) Cytosine (C) Guanine (G) DNA nucleotide Bases Sugar-phosphate backbone Phosphodiester linkages Deoxyribose Chargaff’s Rules • The amount of G, C, A, T varies from species to species. • In all species amount of A = amount of T amount of G = amount of C 34
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Determination of common bond angles and distances allowed for generation of space Flling models O H C Linus Pauling and Robert Corey Protein ! -helix Watson & Crick used model building to determine DNA structure Overall dimensions of DNA determined by X-ray diffraction Rosalind ±ranklin 35
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This note was uploaded on 09/28/2009 for the course BIO 1A taught by Professor Schlissel during the Fall '08 term at Berkeley.

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F08pages33-43 - If mutations are in same gene If mutations...

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