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F08pages60-78 - Insertion or deletion of 3,6,9 base pairs...

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Insertion or deletion of 3,6,9... base pairs preserves reading frame. Summary of the mechanisms of transcription and translation. Chapter 17 Questions 7th Edition 8th Edition Concept Checks – 17.1 (questions 1-2). – 17.2 (questions 1-4). – 17.3 (questions 1-3). – 17.4 (questions 1-3). – 17.5 (question 1). – 17.6 (questions 1-2). – 17.7 (questions 1-2). Self-Quiz Questions 2-3, 5-6, 8-10. Concept Check – 17.1 (questions 1-3). – 17.2 (questions 1-4). – 17.3 (questions 1-3). – 17.4 (questions 1-4). – 17.5 (questions 1-2). – 17.6 (questions 1-2). Figure 17.2, 17.8, 17.24 questions. Self-Quiz Questions 1-8. 60
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Microbes Outline of lecture • Bacteria, plasmids, bacteriophage, transposons • Regulation of prokaryote gene expression - repressors, activators, operators, promoters. Model of Adenovirus Reading Assignment 7th Edition. Chapter 18. Page 334-338. Skip section on Lysogenic cycle. Page 339-348. Skip section on transformation, read section on Conjugation and plasmids, skip F-plasmid/conjugation. Page 351 (from R plasmids and Antibiotic resistance) to chapter end. 8th Edition. Chapter 19, Page 381 - 386. Skip section on lysogenic cycle. Page 387 - 394. 394. Chapter 21, page 435 (Movement of Transposons and Retrotransposons). Chapter 27, Page 559, start at Internal and Genomic Organization) up to 561 (Transformation & Transduction). Then 562 - 564 read sections on Conjugation and Plasmids and R plasmids and antibiotics. Skip sections on F-factor. Chapter 18, Page 351 up to 356 (Eukaryotic gene expression). Why study microbes? Dividing E. coli bacterium Bacteriophage T4 Circular plasmid DNA 61
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Small pox Polio AIDS Small fraction of microbes cause a great amount of disease • Aids • Influenza Small pox • Herpes • Rabies • Cancer • Measles • Polio Black plague • Dysentery • Cholera • Botulism Venereal disease • tuberculosis Viruses Bacteria E. coli bacteria - a model microbe DNA region Membrane Cytoplasm 62
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Plasmids Donor Recipient Cytoplasmic Bridge Circular plasmid DNA Conjugation Putting plasmids into bacteria (transformation) Ampicillin sensitive bacteria Grow on plates with ampicillin Rare bacteria take up the plasmid and form colonies. Ampicillan Resistance Gene Origin of DNA replication Bacterial colonies Bacteriophage 63
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Infection Production of new bacteriophage Lysis 64
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Retrovirus (e.g., HIV) early life cycle Retrovirus late life cycle Retrovirus Summary Inside a retrovirus are 2 copies of its RNA genome as well as the enzyme reverse transcriptase (RT). The RT and the RNA genome were made in the previous host cell. Once inside the new host cell, reverse transcriptase copies the RNA genome into double-stranded DNA. Reverse transcriptase uses the RNA template to make a RNA/DNA duplex and then the RNA is removed as RT uses the DNA strand as a template to form double stranded viral DNA.
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