4.Lung Cancer .pptx - Lung Cancer Bojana Stevich-Heemer MS PharmD MEd BCOP Text \u2022 Lung Cancer in Pharmacotherapy A Pathophysiologic Approach DiPiro et

4.Lung Cancer .pptx - Lung Cancer Bojana Stevich-Heemer MS...

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Lung CancerBojana Stevich-Heemer, MS, PharmD, MEd, BCOP2/17/2020
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TextLung Cancer in Pharmacotherapy A Pathophysiologic Approach - DiPiro et. al. chapter #129, 10th edition
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ObjectivesAfter this presentation a student should be able:Know incidence and mortality rates of lung cancerOutline screening and prevention strategy for lung cancerPresent the most appropriate patient-specific therapy and monitoring for:Small cell lung cancer (SCLC) and Non-small cell lung cancer (NSCLC)
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EpidemiologySecond most common malignancy in U.S.Most common cause of cancer-related deathsHighest incidence of death between 60 and 79 years
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Etiology and PathogenesisDifferent molecular abnormalities in the pathogenesis of lung cancerKRASEGFRALKActivation of proto-oncogenesInhibition of tumor suppressor genes
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Risk FactorsTobaccoAbout 80% of lung cancer deaths are thought to be due to smokingDose-response effectRisk increased with amount and duration of smokingEnvironmental exposureAsbestos, radon, ionizing radiation, benzene, arsenic
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Risk FactorsCoexisting lung diseaseHistory of COPDGenetic predispositionFamily historyRepair of DNA adducts (nucleotide excision repair)
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Screening and PreventionChemoprevention: use of prophylactic medications to prevent cancer developmentCurrently no approved chemoprevention agent
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  • Spring '17
  • Non-small Cell Lung Cancer, Cell Lung Cancer Treatment

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