Lung CancerBojana Stevich-Heemer, MS, PharmD, MEd, BCOP2/17/2020
Text•Lung Cancer in Pharmacotherapy A Pathophysiologic Approach - DiPiro et. al. chapter #129, 10th edition
Objectives•After this presentation a student should be able:•Know incidence and mortality rates of lung cancer•Outline screening and prevention strategy for lung cancer•Present the most appropriate patient-specific therapy and monitoring for:•Small cell lung cancer (SCLC) and •Non-small cell lung cancer (NSCLC)
Epidemiology•Second most common malignancy in U.S.•Most common cause of cancer-related deaths•Highest incidence of death between 60 and 79 years
Etiology and Pathogenesis•Different molecular abnormalities in the pathogenesis of lung cancer–KRAS–EGFR–ALK•Activation of proto-oncogenes•Inhibition of tumor suppressor genes
Risk Factors•Tobacco–About 80% of lung cancer deaths are thought to be due to smoking–Dose-response effect–Risk increased with amount and duration of smoking•Environmental exposure–Asbestos, radon, ionizing radiation, benzene, arsenic
Risk Factors•Coexisting lung disease•History of COPD•Genetic predisposition•Family history•Repair of DNA adducts (nucleotide excision repair)
Screening and Prevention•Chemoprevention: use of prophylactic medications to prevent cancer development•Currently no approved chemoprevention agent
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- Spring '17
- Non-small Cell Lung Cancer, Cell Lung Cancer Treatment