4_13_09 TCA Cycle_shunts_links

4_13_09 TCA Cycle_shunts_links - Biochemistry Sixth Edition...

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Unformatted text preview: Biochemistry Sixth Edition Chapter 17: The Citric Acid Cycle Copyright © 2007 by W. H. Freeman and Company Berg • Tymoczko • Stryer These reactions are readily reversible BUT…. There is a powerful pyrophosphatase that drives the reaction forward Acyl CoA Synthetase Carnitine is derived from Lysine Fatty acid oxidation occurs in the mitochondria Acyl CoA dehydrogenase enoyl CoA hydratase L-3-hydroxyacyl CoA dehydrogenase ß-ketothiolase For odd numbered fatty acid chains Propionyl CoA Carboxylase (biotin containing and similar to pyruvate carboxylase) methylmalonyl CoA mutase colabamin containing Fatty acid breakdown when there is not enough oxaloacetate: Ketone bodies QuickTime and a TIFF (Uncompressed) decompressor are needed to see this picture. http://www.inchem.org/documents/ehc/ehc/ehc207.htm Synthesized by Acetyl CoA Carboxylase Creates a CO 2-biotin-Enzyme intermediate When citrate concentrations are high in the mitochondrion Citrate is transported to the cytoplasm and used to make fatty acids by ATP-citrate lyase Citrate +ATP + CoA + H 2 O acetyl CoA +ADP + P i + oxaloacetate Phosphorylation of Acetyl CoA carboxylase partially inactivates the enzyme...
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4_13_09 TCA Cycle_shunts_links - Biochemistry Sixth Edition...

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