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Unformatted text preview: April 12, 2007 Biology 130 Transcription and Translation Invitro outside the cell In vivo inside the cell In situ in tissue Polyribosome many ribosomes attached to the same mRNA. Each ribosome takes off one of the As on the polyA tail until all the copies are made On the mRNA, there is a stretch of coding that tells it whether it is for inside the cell or outside the cell o Goes on Rough ER if outside o Free ribosome if inside o Each polypeptide has a signal peptide. If it attaches to the signal recognition particle (SRP), the SRP binds to a signal receptor protein on the ER membrane and the polypeptide is put into the ER o To either add or remove the signal peptide, use alternative splicing or transcription factors Final EXAM Outline the pathway of the production and transport of insulin molecule and the action of insulin in the blood o Sugar goes up. Signal recognition pathway o Gene gets turned on o How is protein made o How it is shipped out o How insulin works to regulate blood glucose levels Genomic Mutations o Whole set Chromosomal Mutations...
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This note was uploaded on 09/29/2009 for the course NPB NPB 101 taught by Professor Weidner/wingfield during the Spring '08 term at UC Davis.
- Spring '08