3_1_07 - March 1, 2007 Biology 131 Cell Cell Communication...

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March 1, 2007 Biology 131 Cell Cell Communication (continued) Steps to cell cell communication Signal molecules bind to receptor Find receptors on post-synaptic cleft, integral membrane proteins, some inside cells as well o Difference between those inside cells vs on membrane – POLARITY (permeability of signal molecules) o Examples of inside ones – cholesterol (steroids), vitamin D, thyroxin o Most on the outside are proteins – very polar o Neurotransmitters are very small, need to diffuse fast to cross post synaptic cleft o Hormones are larger – go through bloodstream, diffuse through squamish cell of blood vessel and into cells Pathway of permeable chemicals o Released by exocytosis o Go through bloodstream o Permeate all cells o Only affect cells with signal receptors (proteins) o Receptor lignad complexes are transcription factor Intracellular receptors o Permeable compounds Steroid hormones 1,2,5, hydroxyvitamine D 3 (calcium absorption) thyroid hormone o receptor signal molecule complex is a transcription factor
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This note was uploaded on 09/29/2009 for the course NPB NPB 101 taught by Professor Weidner/wingfield during the Spring '08 term at UC Davis.

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3_1_07 - March 1, 2007 Biology 131 Cell Cell Communication...

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