2_20_07 - Biology 130 Membrane mediated transport Need...

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February 20, 2007 Biology 130 Membrane mediated transport Need proteins embedded in the membrane to facilitate mechanism of transport Transports big molecules out of cell End – exocytosis Passive transport Requires no energy and goes along the concentration gradient Transport proteins span the lipid bilayer of the plasma membrane Solute goes through a channel protein from extracellular fluid into cytoplasm Cystic fibrosis – defective Cl- ion channel protein therefore Cl- channels do not work Gated Channels Allosteric or covalent ligand induced channels Voltage action channel Mechanical channel o Muscle spindles (embedded deep in muscle)\ 1. facilitated ions diffuse by ion channels (gated and non-gated) model for facilitated diffusion dependant on i. amount of the transporter ii. saturation iii. speed of conformation changes (how well hinges work) solute binds on the outside and then protein closes. Protein channel opens and molecule is let out inside.
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