2_1_07 - February 1 2007 Biology 130 Protein Activity Often...

Info iconThis preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon
February 1, 2007 Biology 130 Protein Activity Often due to interactions b/w protein and a ligand. A ligand is any molecule or ion that binds to another molecule. o Neurotransmitters (ligand) – neurotransmitter receptor (protein) o Transport proteins (alpha/beta globulins =>LDL, HDL) (hemoglobin) ligands (cholesterol, O2, CO2) o Hormones = steroidal/non steroidal (ligand) – hormone receptors (protein) o Antibodies (protein) – antigen (foreign body / toxic substance) This binding occurs at a binding site due to electrical attraction or van der Waal’s forces but not covalent bonds (at least usually) Protein ligand interactions are specific to one or several related chemicals The strength or affinity with which the ligand binds depends on how well the ligand fits into the proteins’ three dimensional structure (amino acids and environment chemical specificity) and how strong the attractive forces are (cells can regulate that) (bonds) o Cells can change bonding to shut down or turn on an enzyme when substrate is present The amount of ligands bound to a specific amount of proteins is termed saturation , which is a dynamic phenomenon. Will influence production. Increase saturation by increasing ligand concentration.
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 2
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 09/29/2009 for the course NPB NPB 101 taught by Professor Weidner/wingfield during the Spring '08 term at UC Davis.

Page1 / 3

2_1_07 - February 1 2007 Biology 130 Protein Activity Often...

This preview shows document pages 1 - 2. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online