Lecture 9_BisPhenol A Case Study_Sept 24

Lecture 9_BisPhenol A Case Study_Sept 24 - Bisphenol-A Case...

Info icon This preview shows pages 1–6. Sign up to view the full content.

View Full Document Right Arrow Icon
Bisphenol-A Case Study in Risk Assessment Megan R. Schwarzman, MD, MPH PH 150B – September 24, 2009 University of California, Berkeley School of Public Health Center for Occupational & Environmental Health
Image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
BPA Case Study Risk assessment overview Bisphenol-A (BPA) basics: exposure and effects Challenges for BPA risk assessment 1. Hazard identification: incorporating new science; testing for the right endpoint; association vs. causation 2. Dose-Response: low dose effects; extrapolation 3. Exposure Assessment: variability of exposure 4. Risk Characterization: association vs. causation; vulnerable populations and life stages; industry influence
Image of page 2
Bisphenol-A Timeline 1891 1891: bisphenol-A first synthesized 1930 1930: recognized as a synthetic estrogen 1940’s 1940’s: used to manufacture hard plastics 1988 1988: U.S. EPA sets “safe” exposure level 1997-1999 1997-1999: BPA found in baby bottles and canned formula; first studies show low-dose effects 2003-2006 2003-2006: NTP reviews evidence of BPA toxicity February, 2007 February, 2007: Congress launches conflict-of-interest investigation industry contractor doing NTP review April-June, 2007 April-June, 2007: NTP fires contractor; report unchanged; experts identify 297 flaws in report; January, 2008 January, 2008: Congress orders FDA review basis for “safety” of BPA in infant formula cans; FDA reveals reliance on 2 industry-funded studies April, 2008 April, 2008: Wal-Mart pulls BPA bottles off shelves September, 2008: September, 2008: NTP final report expresses "some concern" for BPA's effects on fetal development October, 2008 October, 2008: Canada restricts BPA; FDA starts re-assessing safety 2009: 2009: States propose BPA bans (CA, CT, MN, NY); Endocrine Society Statement
Image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Determinants of Risk Risk = Risk = f ( f ( hazard x exposure) hazard x exposure) Hazard: Toxicological properties Dose Vulnerable windows of development Exposure: Environmental medium Time course (chronic vs. acute) Potency Timing of exposure
Image of page 4
Steps of Risk Assessment Used by Environmental Agencies Risk Assessment Step Outcome 1. Hazard Identification Level of evidence for disease endpoint (e.g. “likely human carcinogen”) 2. Dose-Response Assessment Disease incidence relative to exposure level; LOAEL/NOAEL 3. Exposure Assessment Human exposure estimates (e.g.
Image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Image of page 6
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern