15 - Lecture 15 November 3 2008 Matrix Remodeling Metalloproteinases(MMPs And ECM remodeling 1(15 Nov 3(16 Nov 5(17 Nov 10 MMPs and matrix

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1 Lecture 15 M atrix R emodeling M etalloproteinases ( MMPs ) And ECM remodeling November 3, 2008
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2 (15) Nov 3 MMPs and matrix remodeling (16) Nov 5 Matrix glycoproteins: laminins and epithelial morphogenesis (17) Nov 10 Fibronectin and integrin activation Nov 12 Term test #2: From HA to lecture 14 255 McCaul Street Exam Centre in Room 200 3:10 – 4:30 P.M. (18) Nov 17 Dr. Christopher McCulloch Director of the CIHR Group in Matrix Dynamics University of Toronto “The role of cell adhesions in diabetic cardiomyopathy” (19) Nov 19 SIBLING family of glycoproteins and tissue mineralization (20) Nov 24 SPARC/osteonectin and collagen IV maturation (21) Nov 26 Elastin: tissue elasticity and resilience (22) Dec 1 Neural crest cell migration and ECM guidance cues (23) Dec 3 ECM and cancer progression
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3 The complexity of adhesion: the integrin adhesome Adhesome or confusome???? Nature Reviews Molecular Cell Biology (2007) 8: on line FAK ILK
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4 “Secreted” MMP domains Zn2+ -binding endopeptidases that degrade components of the ECM Collectively degrade collagen, proteoglycans, glycoproteins, elastin, cell surface receptors, growth factors, and cytokines MMPs are also called “matrixins” Type IV collagen At least 22 MMPs have been found to be expressed in humans
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5 MMP-2 (Gelatinase A) and MMP-9 (Gelatinase B) Pre-peptide Signal peptide) Pro-domain Cysteine switch Hemopexin domain FN Type III repeats Hinge region Catalytic domain MMP2: (Gelatinase A) TIMP-2-proMMP-2 Targets: Gelatin, CI, CV, CX, CIV, LN-5 MMP9: (Gelatinase B) TIMP-1-proMMP-9 Targets: Gelatin, CI, CV, CX, CIV Vu and Werb (2000) Genes and Development 14: 2123-2133
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6 MMP-2 and MMP-9 Pre-peptide Pro-domain ~ 170 a.a.
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This note was uploaded on 09/29/2009 for the course CSB csb327 taught by Professor Ringuitte during the Fall '08 term at University of Toronto- Toronto.

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15 - Lecture 15 November 3 2008 Matrix Remodeling Metalloproteinases(MMPs And ECM remodeling 1(15 Nov 3(16 Nov 5(17 Nov 10 MMPs and matrix

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