5 - Lecture 5 Extracellular Processing and Assembly of Type...

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1 Sept 22, 2008 Lecture 5 Extracellular Processing and Assembly of Type I Collagen Ehlers-Danlos Syndrome Basal Laminae/basement membranes
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2 Lecture Topics and Test Dates (1) Sept 8 Introduction (2) Sept 10 Intracellular processing and transport of ECM molecules Molecular organization of collagens, classification Fibrillar collagens: type I collagen - prototype (3) Sept 15 Connective tissue defects due to the improper assembly of type I collagen in the ER: scurvy and osteogenesis imperfecta (4) Sept 17 Extracellular processing and the supramolecular assembly of type I collagen Collagen defects: Ehlers-Danlos syndrome (EDS) (5) Sept 22 EDS continued Basal laminae/basement membranes: network-forming collagen IV {6) Sept 24 Role of basal laminae in epithelial morphogenesis and kidney filtration (7) Sept 29 Type VII collagens and anchoring fibrils in the dermal-epidermal junction zone
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