7 - September 29, 2008 Lecture 7 Type VII Collagen/...

Info iconThis preview shows pages 1–6. Sign up to view the full content.

View Full Document Right Arrow Icon
1 September 29, 2008 Type VII Collagen/ Anchoring Fibrils Lecture 7
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
2 Lecture Topics and Test Dates (1) Sept 8 Introduction (2) Sept 10 Intracellular processing and transport of ECM molecules Molecular organization of collagens, classification Fibrillar collagens: type I collagen - prototype (3) Sept 15 Connective tissue defects due to the improper assembly of type I collagen in the ER: scurvy and osteogenesis imperfecta (4) Sept 17 Extracellular processing and the supramolecular assembly of type I collagen Collagen defects: Ehlers-Danlos syndrome (EDS) (5) Sept 22 EDS continued Basal laminae/basement membranes: network-forming collagen IV {6) Sept 24 Role of basal laminae in epithelial morphogenesis and kidney filtration (7) Sept 29 Type VII collagen/ anchoring fibrils in the dermal-epidermal junction zone
Background image of page 2
3 Schematic of Normal Skin: Two layers – epidermis and dermis Dermal- Epidermal Junction Zone (DEJZ) Epithelial mesenchyme interactions Skin is the largest organ in our body dermis epidermis
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
4 Histology of the skin Iowa Department of pathology Two layers Epidermis - epithelial tissue- rich in keratinocytes Dermis – connective tissue – rich in fibroblasts and ECM Stratum corneum: cornified layer of dead, protective cells Stratum granulosum: Granule-cell layer, keratinhyalin granules, degradation of nuclei and organelles Stratum spinosum: “prickle-cell layer”, differentiating keratinocytes Stratum basale/ Germinativum: basal cell layer, undifferentiated cells Basal lamina Shed ~ 2 gm/day
Background image of page 4
5 The Dermal-Epidermal Junction Zone (DEJZ) A-anchoring filaments (laminin-based) HD-hemidesmosomes L-lamina rara D-lamina densa F- anchoring fibrils C-type I collagen fibrils Basement Membrane (anchoring Fibrils & Basal Lamina) BL DEJZ
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 6
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 09/29/2009 for the course CSB csb327 taught by Professor Ringuitte during the Fall '08 term at University of Toronto- Toronto.

Page1 / 21

7 - September 29, 2008 Lecture 7 Type VII Collagen/...

This preview shows document pages 1 - 6. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online