9 - October 6, 2008 Lecture 9 The Proteoglycans Hyaluronan...

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1 October 6, 2008 Lecture 9 The Proteoglycans Hyaluronan and Aggrecan
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2 (8) Oct 1 Transmembrane and FACIT collagens: skin blistering and cartilage defects Proteoglycans (9) Oct 6 Hyaruronan, aggrecan and chondrogenesis (10) Oct 8 Aggrecan and cartilage defects Perlecan: endochondral ossification and chondrodysplasis Oct 13 Thanksgiving – University closed Oct 15 Term Test #1: collagens (11) Oct 20 Small leucine-rich proteoglycans (SLRPs): Decorin and biglycan and osteogenesis (12) Oct 22 Transmembrane proteoglycans: syndecan and growth factor signaling (13) Oct 27 Integrins and cell-matrix adhesion (14) Oct 29 Matrix remodeling metalloproteinases, ECM remodeling and cancer
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3 Schematic diagram of endochondral ossification Committed cartilage Proliferating chondrocytes condensation Hypertrophy Apoptosis mineralization Angiogenesis arrival of osteoblasts Cartilaginous template
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4 Schematic diagram of cartilage formation mesenchymal Prechondrocyte NCAM, N-cadherin Sox9 Reserve chondrocyte Proliferating chondrocyte Prehypertrophic chondrocyte Hypertrophic chondrocyte BMPs FGFs Wnts BMPs BMPs VEGF Collagen II Aggrecan HA CD44 BMP-bone morphogenic protein; FGF-fibroblast growth factor; VEGF – vascular endothelial growth factors
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“physis”: can mean to grow “Epiphysis”: The growth area near the end of a bone. “Metaphysis”:the growing part of a long bone between the diaphysis and the epiphysis “diaphysis”: the growing part of a long bone between the diaphysis and the epiphysis www.eorthopod.com/images/ContentImages/child/. .. www.eorthopod.com/public/patient_education/66. .. Femoral epiphysis
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9 - October 6, 2008 Lecture 9 The Proteoglycans Hyaluronan...

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