11 - Lecture 11 October 20, 2008 Perlecan and...

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1 Lecture 11 October 20, 2008 Perlecan and chondrodysplasias Small leucine-rich proteoglycans and collagen fibrillogenesis
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2 (8) Oct 1 Transmembrane and FACIT collagens: skin blistering and cartilage defects Proteoglycans (9) Oct 6 Hyaruronan, aggrecan and chondrogenesis (10) Oct 8 Aggrecan and cartilage defects Perlecan: endochondral ossification and chondrodysplasia Oct 13 Thanksgiving – University closed Oct 15 Term Test #1: collagens (11) Oct 20 Small leucine-rich proteoglycans (SLRPs): Decorin and osteogenesis (12) Oct 22 Transmembrane proteoglycans: syndecan and growth factor signaling (13) Oct 27 Integrins and cell-matrix adhesion (14) Oct 29 Matrix remodeling metalloproteinases, ECM remodeling and cancer
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3 Shrinkage of the cartilage proteoglycans and increased spaces with increasing age. www.shoulderdoc.co.uk/. ../article.asp?article=7
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4 Formation of the epiphyseal growth plates by chondrocytes which proliferate before undergoing hypertrophy
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5 Skeletal Mineralization in 19-day chick embryos Shell-less culture Inside an egg during normal culture The embryos were fixed and stained with Alizarin red to show the calcified bone matrix
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6 Structures of representative members of each proteoglycan expressed in cartilage Schwartz and Domowicz.2002. Glycobiology 12: 57R-68R. Aggrecan Perlecan Lecture 11 Syndecans Decorin
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7 The Domain Organization of the glypican family of PGs Perlecan Agrin Bamacan Type XVIII collagen 400 kDa Core protein HS-GAGs
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Structural domains of human perlecan: cell growth and differentiation and tissue organization 2-3 HS chains Five distinct structural domains 400 kDa Core protein Present in all basal laminae/ basement membranes in the ECM of growth plates and articular cartilage where it contains both HS and CS chains Name derived from rotary shadow images- the core protein looks like a “string of pearls”
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This note was uploaded on 09/29/2009 for the course CSB csb327 taught by Professor Ringuitte during the Fall '08 term at University of Toronto- Toronto.

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11 - Lecture 11 October 20, 2008 Perlecan and...

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