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Unformatted text preview: 1 Lecture 13 October 27, 2008 INTEGRINS Read pages 1113-1115 in Alberts 4th edition Arcangells and Georges-Labouesse (2000) Integrins and ECM functions: role in vertebrate development. Trends in Genetics 16: 389-395 Abstract The analysis of mutant mice is bringing novel insights on the role of ECM and integrin receptors during a variety of physiological processes, including embryonic development. The requirement of these adhesion molecules in epithelial morphogenesis or histogenesis in organs such as kidneys and lungs, in limbs, and the development of mesoderm and the nervous system have been unraveled by the study of single or compound mutants. Their role in tissue integrity has also been highlighted. Models have been produced that should prove very useful in defining the cellular mechanisms and the function and ECM signaling cascades in vitro. Overview Integrins are heterodimeric transmembrane receptors composed of noncovalently associated α and β chains. In mammals, 24 integrin heterodimers have been identified, which recognize ECM components (laminins, collagens, fibronectins, and others) was well as counter-receptors (I-CAMs) on the surface of neighboring cells. Many integrins can bind several ligands, and generally, one ligand is recognized by several integrin heterodimers. As has become obvious during recent years in studies of cultured cells, focal adhesions, the site where cell contact the ECM via integrins, are extremely dynamic multimolecular complexes that link integrins to the cytoskeletal network and intracellular signalling pathways. Knock-out of genes coding most integrin chains has been performed in mice over recent years and has demonstrated their essential role in many developmental processes, in particular the β 1 subfamily. 1 subfamily....
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This note was uploaded on 09/29/2009 for the course CSB csb327 taught by Professor Ringuitte during the Fall '08 term at University of Toronto.
- Fall '08