SI session Nov. 13 Ch. 14

SI session Nov. 13 Ch. 14 - Kaiser Imam November 13, 2007...

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Kaiser Imam November 13, 2007 BIOL 215 SI Session Chapter 14 Chapter 14: Signal Transduction 1. Receptor tyrosine kinases (RTKs) consist of _________ polypeptide chain(s) with ________ transmembrane segment(s) in the shape of a(n) _____________________. 2. The cytosolic side of a receptor tyrosine kinase has two parts: a __________________ domain and a __________________ that contains residues of the amino acid ____________. 3. The extracellular side of the RTK has a _________________________________. 4. The binding of a ligand causes receptor tyrosine kinases to __________________. In situations where two proteins do this the process is called _________________. The process by which the RTKs phosphorylate each other in a process called ______________________. 5. The ligand that binds to the RTK to start off the Ras pathway is __________________________________________. 6. Ras is a _______________________ G protein that is involved in regulating the __________ and _____________ of cells. Like many G proteins, Ras is in its active state when it is bound to _________ and inactive when bound to _________. The type of protein that makes the exchange of these molecules possible is called a ________________________________. 7. The guanine-nucleotide exchange factor (GEF) that activates Ras is called ___________. This GEF forms a complex with a protein called _____________ in order to bind to a receptor tyrosine kinase. 8. Ras can be deactivated by hydrolyzing the GTP molecule bound to it to GDP. This process is mediated by a ____________________________________________. 9. Before its activation by Sos Ras is anchored to the plasma membrane by a _______________ attachment to a ________________ molecule. 10. What are SH2 domains? Give two examples of proteins with SH2 domains that were mentioned in class. 1
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SI session Nov. 13 Ch. 14 - Kaiser Imam November 13, 2007...

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