8-28-09 - Morphogenesis vs Differentiation Morphogenesis:...

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Morphogenesis vs Differentiation Morphogenesis: generation of the proper spatial organization of a tissue or organism Differentiation: generation of cellular diversity
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Dolly, the clone Dolly, all grown up Genomic equivalence and Totipotency
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Clones are not necessarily identical
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Contact and recognition between sperm and egg Fusion of two cells. Regulation of sperm entry – only one Fusion of two haploid gamete genomes Activation of egg metabolism Reactivation of the cell cycle In the beginning: Fertilization
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The concept of preformation
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Gametes: Sperm sperm – spermatozoa: “sperm animals” very little cytoplasm motility due to microtubules in axoneme Acrosomal vesicle contains enzymes necessary for fertilization
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Sperm motility is microtubule based 9 by 2 arrangement Kartagener syndrome: infertility and situs inversus protofilaments
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The structure of the egg
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The egg cytoplasm is concentrated in egg during meioses contains proteins, mRNA necessary for initial development Fig 7.5
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extracellular matrix, involved in sperm recognition. Sea urchin
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8-28-09 - Morphogenesis vs Differentiation Morphogenesis:...

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