final_exam_2009-answers

final_exam_2009-answers - Name:_ Principles of Drug Action...

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Name:____________________________ Principles of Drug Action (BIO 365D) Final Exam May 14, 2009 Each of the 30 multiple choice questions is worth 0.5 marks (for a total of 15 out of 40) . 1. Heroin is produced by the diacetylation of morphine, which itself can be purified from the opium poppy plant. Heroin is thus an example of A. A Galenical B. A pure compound C. A natural preparation D. A semi-synthetic compound E. A synthetic compound 2. A drug’s partition coefficient is described by which of the following? A. C oil - C water B. C water - C oil C. C oil ÷ C water D. C water ÷ C oil E. C oil × C water 3. Which one of the following statements is TRUE ? A. Gap junctions permit the passage of small molecules between cells of different tissue types. B. The basement membrane adjacent to epithelial cells acts as a barrier to drug permeation. C. Occluding zonulae make tight junctions between epithelial cells and also between cells that make up the blood:brain barrier. D. Gap junctions are composed of proteins called aquaporins. E. Capillaries with maculae are found at high levels in excretory and secretory organs. 4. Which one of the following statements is FALSE ? A. Proteins are not filtered in the glomerulus. B. The thin section of the ascending loop of Henle is permeable to water, but impermeable to solute, especially sodium and chloride ions. C. Urea within the interstitium of the medulla plays a role in concentrating urine. D The thick section of the ascending loop of Henle and early distal tubule are virtually impermeable to water. E Antidiuretic hormone (ADH) acts to make the distal tubule and the collecting duct become more permeable to water. 5. Which one of the following statements is FALSE ? A. For a highly protein-bound the percentage of drug in the unbound state might be expected to increase if a patient is suffering from liver disease. B. When drugs redistribute from blood to various tissues within the body, uptake is slowest in the VPG of tissues. C. The heart is an example of a tissue belonging to the VRG of tissues. D. Increasing binding to plasma proteins would be expected to decrease the half life of a drug. E. When drugs exit the body, redistributing from tissue to blood, the concentration drops off most quickly in the VRG.
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Name:____________________________ 6. Which one of the following statements about the figure below is TRUE ? A. The dashed line shows the effect of a partial agonist, while the solid line depicts the effect of a full agonist. B. The drug producing the dashed line has higher potency than the drug producing the solid line. C. The drug producing the dashed line has a higher efficacy than the drug producing the solid line. D.
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This note was uploaded on 09/29/2009 for the course PHY 317L taught by Professor Ritchie/lang during the Spring '08 term at University of Texas.

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final_exam_2009-answers - Name:_ Principles of Drug Action...

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