ZOL341_SS07_Lecture21

ZOL341_SS07_Lecture21 - Last Class DNA Mutation How do...

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Unformatted text preview: Last Class DNA Mutation How do mutations affect us Cheetas recent birthday What/where are the checks and balances? Cell cycle of a mammalian cell in tissue culture Main events in a cell cycle All of these events except the duplication of DNA in the chromosomes are cytologically visible The cell cycle of budding yeast, Saccharomyces cerevisiae Use of heat-sensitive mutations to decipher the timing of a genes function in the cell cycle Cell division cycle ( cdc ) mutants cdc13 DNA content of the wild type and a cell cycle mutant strain at permissive and restrictive temperatures The wild type cells have similar distribution of haploid and diploid DNA content at both temperatures. The mutant cells resemble the wild type cells at the permissive temperature. At the restrictive temperature in the mutant, cells with diploid DNA content accumulate because division to regenerate cells with haploid DNA content is blocked. Events that trigger arrests at cell cycle checkpoints Mitotic Exit Network Metaphase to anaphase transition requires the activation of anaphase-promoting complex Events involved in the activation of the spindle checkpoint Spindle Position Checkpoint Failure = extra nucleus Mitotic Exit Network Events that trigger arrests at cell cycle checkpoints Cell division cycle ( cdc ) mutants found to be cyclin-dependent protein kinase Cell cycle is highly conserved Controlled by cyclin and cdk proteins Rise and fall in the concentrations of the various cyclins during the 4 stages of the cell cycle Timing of synthesis and destruction of Cyclin + Cyclin-dependent protein kinase (Cdk) complexes during cell cycle Events that trigger arrests at cell cycle checkpoints Retinoblastoma (RB) and cdc 6 proteins are involved in the transition from G1 -> S Steps in the cell cycle controlled by p53 protein after DNA damage...
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ZOL341_SS07_Lecture21 - Last Class DNA Mutation How do...

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