Lecture six 10 08 08

Lecture six 10 08 08 - How toxic? Venomous Poisonous oral,...

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How toxic? Poisonous Venomous oral, dermal injected
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0.02 mg/Kg LD 50 Black banded sea snake Death cap 0.1 mg/Kg 0.9 mg/Kg Black widow
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Most potent poisons/venoms 0.1 mg/Kg 0.020 mg/Kg 0.003 mg/Kg Ricin Castor bean
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Georgi Markov Ricin pellet injected Murdered by KGB
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0.003 mg/Kg Ricin Botulinum 0.000001 mg/Kg Bacterium 0.1 mg/Kg 0.020 mg/Kg 1 nanogram
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Botox 0.003 mg/Kg Ricin Botulinum 0.000001 mg/Kg Bacterium
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Amatoxins Protoplasmic toxins Exposed cells quickly die Inhibits RNA polymerase Inhibit RNA polymerase II Amatoxins inhibit RNA polymerase II An enzyme required for protein synthesis
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Stop protein synthesis Inhibit RNA polymerase II DNA X Prevents formation of messenger RNA enzyme m-RNA Protein synthesis
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Amatoxins causing abdominal pain, vomiting, diarrhea symptoms appear after 8-12 hours First effect is death of epithelial cells in GI tract
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Symptom progression Abdominal pain, vomiting, diarrhea persists for up to 48 hours Remission of symptoms 48-72 hours >72 hours Symptoms return + Jaundice liver failure and death Symptoms appear after 8-12 hours
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Lecture six 10 08 08 - How toxic? Venomous Poisonous oral,...

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