Lecture nine 10 17 08

Lecture nine 10 17 08 - Sputnik 1957 LSD was already...

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Sputnik 1957
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The world was ready for the magic mushroom LSD was already available
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‘Fulfilled his obligation as a scholar to report his discoveries’
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Mind-control Truth serum Joined Wasson expedition Obtain mushrooms for testing James Moore - chemist Identify the cause of hallucinations Not successful Look into the future
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How could the cause be identified?
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Dog Bioassay Test for biological activity
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Dog Bioassay Test for biological activity Before After No effect on dogs During
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Volunteers? Dose = 32 dried mushrooms This stuff definitely works Albert Hoffman Sandoz Corp.
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Bioassay on volunteers Extract and purify chemicals
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Psilocybin Psilocin Conversion occurs in the body
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LD 50 = 280mg/kg Effective dose of psilocin = 0.5mg/Kg Actively excreted: 2/3 of dose removed within 3 hours No reports of human fatalities Psilocin = hallucinogenic principle rats
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“same power as mushroom” Maria Sabina Consumed 30mg of pure psilocin
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Psilocin Tryptophan Essential amino acid
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Tryptophan Essential amino acid Sleeping aid Anti-depressant
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This note was uploaded on 10/03/2009 for the course SAS 30 taught by Professor Wilhelm during the Fall '08 term at UC Davis.

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Lecture nine 10 17 08 - Sputnik 1957 LSD was already...

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