5%20Liver%20Function%20Tests - LIVER FUNCTION TESTS (LFT)...

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LIVER FUNCTION TESTS (LFT) Type of Test Adult Normal Value Indication ORGANIC ION TRANSPORT Bilirubin Bilirubin is derived from the breakdown of hemoglobin. Lab values reflect ability of the liver to excrete bilirubin. Total bilirubin (conjugated & unconjugated) 0.1-0.2 mg/dL Elevated with liver biliary obstruction. Indirect bilirubin (unconjugated) 0.1-1.0 mg/dL Abnormalities in indirect bilirubin indicate excess RBC hemolysis or liver disease Direct bilirubin (conjugated) 0.1-0.3 mg/dL Bilirubin is conjugated (made water soluble by the liver. Abnormalities in direct bilirubin generally indicate biliary obstruction. Urinary bilirubin neg.-0.02 mg/dL Unconjugated bilirubin can not be excreted by the kidneys. Positive urinary bilirubin results from biliary tract obstruction (hyperbilirubinemia). Urobilinogen (urine) 0.3-3.5 mg/dL (random) Conjugated bilirubin from bile is changed in duodenum to urobilinogen, some of which is absorbed by gut and excreted by the kidney. CHOLESTASIS Alkaline phosphatase (ALP) ALP1: liver, vascular. endothelium, lung ALP2: bone, kidney, placenta ALP3: intestinal mucosa 30-120 IU/L Increase in infiltrative liver disease, neoplastic metastases, and in chronic obstruction of the biliary tract. Not specific for liver disease; alkaline phosphatase produced in the liver, bone, small intestine. When alkaline phosphatase is elevated, must rule out bone disease by determination of another cholestatic indicator enzyme that is absent from bone, e.g. gamma glutamyl transpeptidase, leucine amino peptidase or 5' nucleotidase or by electrophoretic separation of alkaline phosphatase isoenzymes. 5'-Nucleotidase (5'NT or 5'N) < 14 U/L 5'NT is specific to liver cells. Both ALP and 5'NT are elevated in cholestatic disease. Gamma-glutamyl
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This note was uploaded on 10/04/2009 for the course NTR 371 taught by Professor Southworth during the Spring '09 term at University of Texas at Austin.

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5%20Liver%20Function%20Tests - LIVER FUNCTION TESTS (LFT)...

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