Liver%20Disease%20Lecture%20Notes%201%20slide

Liver%20Disease%20Lecture%20Notes%201%20slide - LIVER...

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LIVER DISEASE
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iver Liver “ owerhouse of the body” Powerhouse of the body Largest organ in body ~3 5 pounds 3.5 pounds Size of a football nly require ~20% Only require 20% of liver function Accounts for 26% basal metabolic rate
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epatic Blood Flow Hepatic Blood Flow Receives 30% of cardiac output 10-15% of total blood volume is sequestered in the liver at any time Blood flow of 1400 ml per minute ~70% nutrient rich, deoxygenated blood from digestive tract via portal vein ~30% oxygenated blood from aorta via hepatic yg p artery
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ascular Functions Vascular Functions ortal vein: 1000 mL/min Portal vein: 1000 mL/min Average pressure 8 mm Hg Hepatic vein: 400 mL/min p Average pressure 0 mm Hg Liver can become a storage reservoir for blood Pressure of 4-8 mm Hg in hepatic vein results in storage of 200-400 ml blood in the liver Increase to 10-15 mm Hg in hepatic vein causes pathological changes Portal hypertension Ascites sophageal and/or gastric varices Esophageal and/or gastric varices
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iver Functions Liver Functions Metabolic Regulation of blood glucose levels Secretory Bile Regulation of blood lipid levels ynthesis of plasma Excretory Bilirubin Cholesterol Synthesis of plasma proteins Storage Some hormones Detoxification Glycogen Vitamins & minerals Ammonia EtOH ome drugs Some drugs
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iver Function Tests (LFTs) Liver Function Tests (LFTs) Serum bilirubin: direct and total Urine bilirubin Aminotransferases: ALT and AST lkaline phosphatase Alkaline phosphatase Total protein with albumin and globulin Prothrombin time Pratt and Kaplan, 2003
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tiology of Liver Disease Etiology of Liver Disease Viral Infections Damage from hepatotoxic substances such s alcohol as alcohol Ischemia from trauma or surgery utoimmune insults Autoimmune insults Neoplastic Disease Inherited diseases such as Wilson’s Disease Total Parenteral Nutrition
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lcohol Alcohol Per capita consumption 4-5% of kcal in average American diet > 10% in adult drinkers 50% of kcal for heavy drinkers Alcohol abuse Chronic consumption of > 80 g ethanol per day 6 shots of 80-proof liquor 6 glasses of wine (5 oz) 6 beers (12 oz) US statistics 85,000 deaths annually Economic loss of $186.6 billion annually
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lcohol Content Alcohol Content Beer: 3.8% alcohol 360 mL (12 oz) x 0.038 = 13.7 g alcohol Wine: 12-14% alcohol 150 mL (5 oz) x 0.13 = 19.5 g alcohol Distilled spirits: 40-55% alcohol (80-110 proof) 0 proof: 45 mL (1 jigger/1.5 oz) x 0.40 = 18 g alcohol 80 proof: 45 mL (1 jigger/1.5 oz) x 0.40 18 g alcohol
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lcohol Kcal Alcohol Kcal cal estimate = ounces x proof x 0 8 Kcal estimate = ounces x proof x 0.8 Proof = proportion of alcohol to water 100 proof = ~50% alcohol .8 kcal/proof/ounce 0 8 ca /p oo /ou ce Caloric density of ~ 7 kcal/g Adjusted for proportion of alcohol available for energy Example 6 12-oz cans of 4% beer 72 oz x 8 proof x 0.8 = 460.8 kcal
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This note was uploaded on 10/04/2009 for the course NTR 371 taught by Professor Southworth during the Spring '09 term at University of Texas at Austin.

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Liver%20Disease%20Lecture%20Notes%201%20slide - LIVER...

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