Lect7 - B and T Four beta strands from each of the variable...

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• Protein Structure and Function in the Immune System
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Fig. 15-1 B and T
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Ig (immunoglobulin) structure B and T Fig 15-2
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Fig. 15-3 B and T
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Fig. 5-24 Lehn
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B and T Fig 15-5 Antibody diversity is generated frst by gene rearrangement
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V L C L V H C H 1 Fig. 15-6 B and T
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Fig. 5-23 Lehn
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Fig. 5-23 Lehn
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A constant domain of an Ig chain (antiparallel beta barrel) B and T 15-7
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Fig. 15-8 B and T Comparison of the structures of a constant and of a variable domain
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Fig. 5-23 Lehn
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Fig. 15-9 B and T Variable and constant domains in Ig chains
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B and T 15-10 Packing of the beta sheets from the constant domains of the heavy and light chains
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The V H and V L domains pack together differently than do the constant domains from the two chains B and T 15-11 Like this Not like this
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Fig. 15-12
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Unformatted text preview: B and T Four beta strands from each of the variable domains (V H and V L ) each form half of a beta barrel B and T 15-13 Space-flling model oF the hypervariable regions oF an ab Fragment Complex between lysozyme (antigen - in green ) and antibody ( blue and yellow ) Regions of contact are red . B and T 15-15 Environment of Gln 121 (purple in previous slide) in the lysozyme-antilysozyme complex B and T 15-16 Fig. 5-27 Lehn Fig. 5-27 Lehn Fig. 5-27 Lehn Fig. 5-27 Lehn Antibodies can be used to probe for proteins that are only a small percentage of a complex mixture (immunoblotting) Antibodies can be used to visualize specific types of cells in a tissue...
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Lect7 - B and T Four beta strands from each of the variable...

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