prob set 2

prob set 2 - Problem Set 2 Explain the phenomena: Mutation...

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9 Problem Set 2 Explain the phenomena: Mutation rates increase with target size. 1. In comparing homologous DNA sequences of different species, there are more differences in intron sequences than in exon sequences of genes. Why would this be expected? In comparing exon and intron sequence variation among closely related species, what differences would you expect? 2. The nucleotide sequences of restriction sites are usually palindromic; that is, the 5’ to 3’ sequence of both strands of the site is identical. For example, the sequence recognized and cleaved by the restriction endonucleases Eco RI is 5’ – G A A T T C – 3’ 3’ – C T T A A G – 5’ What is the advantage to restriction sites being palindromic? 3. What is the difference between the “introns early” and “introns late” hypotheses for the evolution of interrupted genes? What evidence in support of these hypotheses is there? 4. Why is the phrase “one gene, one polypeptide” no longer an accurate way of describing the
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This note was uploaded on 10/07/2009 for the course GEN 409 taught by Professor Linda during the Fall '09 term at Iowa State.

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prob set 2 - Problem Set 2 Explain the phenomena: Mutation...

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