opt rdg 1 - THE JOURNAL OF BIOLOGICAL CHEMISTRY 2005 by The...

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Arthur Kornberg’s Discovery of DNA Polymerase I Enzymatic Synthesis of Deoxyribonucleic Acid. I. Preparation of Substrates and Partial Purification of an Enzyme from Escherichia coli (Lehman, I. R., Bessman, M. J., Simms, E. S., and Kornberg, A. (1958) J. Biol. Chem. 233, 163–170) Enzymatic Synthesis of Deoxyribonucleic Acid. II. General Properties of the Reaction (Bessman, M. J., Lehman, I. R., Simms, E. S., and Kornberg, A. (1958) J. Biol. Chem . 233, 171–177) Arthur Kornberg was born in Brooklyn, New York in 1918 and was educated in its public schools. He received his undergraduate degree in science from the City College of New York in 1937 and an M.D. degree from the University of Rochester in 1941. After a 1-year internship in internal medicine, he served as a commissioned officer in the U. S. Public Health Service. He was first assigned to the Navy as a ship’s doctor and then as a research scientist at the National Institutes of Health (NIH) in Bethesda, Maryland, from 1942 to 1953. He obtained training in enzymology with Severo Ochoa at New York University School of Medicine in 1946 and with Carl Cori at Washington University School of Medicine in 1947. Both Ochoa and Cori were authors of Journal of Biological Chemistry (JBC) Classics (1, 2), and additional infor- mation on Kornberg’s research in these laboratories can be found in his JBC Reflections (3). Upon returning to Bethesda, Kornberg organized and directed the Enzyme Section at the NIH. He resigned in 1953 with the rank of Medical Director to assume the chairmanship of the Department of Microbiology at the Washington University School of Medicine in St. Louis, Missouri. In 1959, he organized the Department of Biochemistry at the Stanford University School of Medicine, serving as its chairman until 1969 and thereafter as professor. He accepted the title of Professor Emeritus in 1988 and has been on active status to the present. From his early studies of the mechanisms of the enzymatic synthesis of coenzymes and inorganic pyrophosphate, Kornberg extended his interest to the biosynthesis of the nucleic acids, particularly DNA. After elucidating key steps in the pathways of pyrimidine and purine
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opt rdg 1 - THE JOURNAL OF BIOLOGICAL CHEMISTRY 2005 by The...

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