opt rdg 1 - THE JOURNAL OF BIOLOGICAL CHEMISTRY 2005 by The...

Info icon This preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon
Arthur Kornberg’s Discovery of DNA Polymerase I Enzymatic Synthesis of Deoxyribonucleic Acid. I. Preparation of Substrates and Partial Purification of an Enzyme from Escherichia coli (Lehman, I. R., Bessman, M. J., Simms, E. S., and Kornberg, A. (1958) J. Biol. Chem. 233, 163–170) Enzymatic Synthesis of Deoxyribonucleic Acid. II. General Properties of the Reaction (Bessman, M. J., Lehman, I. R., Simms, E. S., and Kornberg, A. (1958) J. Biol. Chem . 233, 171–177) Arthur Kornberg was born in Brooklyn, New York in 1918 and was educated in its public schools. He received his undergraduate degree in science from the City College of New York in 1937 and an M.D. degree from the University of Rochester in 1941. After a 1-year internship in internal medicine, he served as a commissioned officer in the U. S. Public Health Service. He was first assigned to the Navy as a ship’s doctor and then as a research scientist at the National Institutes of Health (NIH) in Bethesda, Maryland, from 1942 to 1953. He obtained training in enzymology with Severo Ochoa at New York University School of Medicine in 1946 and with Carl Cori at Washington University School of Medicine in 1947. Both Ochoa and Cori were authors of Journal of Biological Chemistry (JBC) Classics (1, 2), and additional infor- mation on Kornberg’s research in these laboratories can be found in his JBC Reflections (3). Upon returning to Bethesda, Kornberg organized and directed the Enzyme Section at the NIH. He resigned in 1953 with the rank of Medical Director to assume the chairmanship of the Department of Microbiology at the Washington University School of Medicine in St. Louis, Missouri. In 1959, he organized the Department of Biochemistry at the Stanford University School of Medicine, serving as its chairman until 1969 and thereafter as professor. He accepted the title of Professor Emeritus in 1988 and has been on active status to the present. From his early studies of the mechanisms of the enzymatic synthesis of coenzymes and inorganic pyrophosphate, Kornberg extended his interest to the biosynthesis of the nucleic acids, particularly DNA. After elucidating key steps in the pathways of pyrimidine and purine
Image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Image of page 2
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern