Cytoskeleton

Cytoskeleton - CYTOSKELETON CHAPTER 17 LECTURE 20 1....

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Unformatted text preview: CYTOSKELETON CHAPTER 17 LECTURE 20 1. Introduction 2. Cytoskeletal cellular distributions 3. Intermediate Filaments 4. Microtubules 1. Introduction- The Cytoskeleton : A network of filaments or tubes composed of protein subunits. Cytoskeletal proteins are found throughout the cytoplasm. Some are found in the nucleoplasm. Procaryotic cytoskeletal proteins are found in mitochondria and chloroplasts. - All subunits are held together by non-covalent bonds.- Subunits are small and diffusible.- Filaments are the most economical (energy, time, and space) way of constructing large, stable structures.- The cytoskeleton is composed of three filamentous structures : * Intermediate filaments * Microtubules * Actin filaments (aka: microfilaments, F-actin)- What Does the Cytoskeleton Contribute? * Cell motility (crawling, flagella/cilia) * Intracellular motility; organelle positioning; cytoplasmic order: organelle, vesicle/ chromosome, mRNA, ribosomes, protein, intracellular signals, pathogen motility * Cell shape and support, tissue support Listeria: motility in infected fibroblast. Actin polymerization drives bacterial locomotion through host cytoplasm. - What Does the Cytoskeleton Contribute? * Cell motility (crawling, flagella/cilia) * Intracellular motility; organelle positioning; cytoplasmic order: organelle, vesicle/ chromosome, mRNA, ribosomes, protein, intracellular signals, pathogen motility * Cell shape and support, tissue support- Accessory Proteins: A diverse population of proteins that bind to filaments or subunits to control sites of filament assembly, regulate filament assembly and disassembly, and control motility of cell and cytoplasmic components Vale and Milligan, Science 288, 88 (2000), http://www.sciencemag.org/feature/data/1049155s2.mov 2. Cytoskeletal cellular distributions Intermediate Filaments Microtubules F-actin 3. Intermediate Filaments- General Characteristics * Tough and durable ropelike fibers * Made of intermediate filament proteins...
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Cytoskeleton - CYTOSKELETON CHAPTER 17 LECTURE 20 1....

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