2008 1st Midterm Exam Key

2008 1st Midterm Exam Key - Cellular Neurobiology / BIPN...

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Cellular Neurobiology / BIPN 140 Name__ ______KEY_____________ FIRST MIDTERM EXAMINATION Fall, 2008 GENERAL INSTRUCTIONS 1. Please write your name on ALL 6 pages. 2. Please answer each question IN THE SPACE ALLOTTED. 3. For full credit, state your assumptions and show your calculations. 1) _______/10 pts Wei 2) _______/10 pts Ryan 3) _______/10 pts Wei 4) _______/10 pts Lydia 5) _______/10 pts Lydia 6) _______/20 pts Rod 7) _______/15 pts Ryan 8) _______/15 pts Eugene 9) _______/10 pts EXTRA CREDIT Eugene TOTAL ___________/100 pts WAIVER : By signing this waiver I give permission for this exam to be left for me to pick up in the vestibule by the elevator on the 3rd floor of Pacific Hall. I understand that I may only pick up my own exam. I realize that the Department of Biology and its staff cannot take responsibility for exams, which may be stolen or lost, from this area. If I choose not to sign this waiver, I acknowledge that my exam will only be available for pickup 1:30-2:30 p.m., Monday- Friday from 3140 Pacific Hall. ____________________________________ ______________________________ 1. Glial cells: 1
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Cellular Neurobiology / BIPN 140 Name__ ______KEY_____________ a). Name the three types of glial cells in the central nervous system (CNS); name one type of glial cell in the peripheral nervous system (PNS). 4 pts The three types of cells in CNS are oligodendroglia, astrocytes, and microglia. Schwann cells are found in PNS. b). Glial cells have rapid and slow functions. Give three examples of each. Rapid functions: 3 pts 1). They make up myelin which speeds up the conduction of action potentials. 2). Some glial cells take up K+ ions to prevent unwanted signaling 3). Glial cells can release neurotransmitters that can affect neurons and other glia. 4). Glial cells can take up neurotransmitters. Slow functions: 3 pts 1). Astrocytes form the bloodbrain barrier around capillaries. 2). Formation of neuronal connections during development. 3). Specificity of regeneration. 4). Scavenging function of microglia 2. The best understood transmembrane ion exchanger is the Na+/K+ pump. a). What are four important domains of the Na+/K+ pump? 4 pts Na+ and K+ binding site ATP binding site Phosphorylation site Oubain binding site b). How is the pump electrogenic? How does this contribute to electrical properties of the neuron? 3 pts This pump exchanges three Na+ from inside with 2 K+ from outside, effectively removing a single cation ion from inside the cell with each exchange. The pump maintains a constant intracellular concentration of Na+ in the face of Na+ influx from action potentials. In addition, it helps establish the resting membrane potentia l to varying extents in different cells. c). How can you demonstrate the K+ and energy dependencies of the operation of this pump?
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2008 1st Midterm Exam Key - Cellular Neurobiology / BIPN...

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