Lect-3-SV - 10-01-09: Lecture 3 Proteins (polypeptides)...

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Proteins (polypeptides) Four levels of protein Structure Primary Structure (1° structure): Secondary Structure (2° structure): Tertiary Structure (3° structure): Quaternary Structure (4° structure): 10-01-09: Lecture 3
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Proteins (polypeptides) Four levels of protein Structure 1° structure 2° structure Beta pleated sheet Alpha-helix 10-01-09: Lecture 3
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Proteins (polypeptides) Four levels of protein Structure 3° structure 10-01-09: Lecture 3
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Proteins (polypeptides) Four levels of protein Structure 4° structure 10-01-09: Lecture 3
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Normal RBC RBC from sickle cell patient One mistake in primary structure……. 10-01-09: Lecture 3
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Proteins and their environment Cellular environment is important for protein conformation (3D structure) and thus protein function pH Salt concentration temperature 3D structure of proteins is held together by non-covalent bonds Proteins can therefore be denatured Chaperone proteins help proteins fold (see figure 5.23 – Campbell) 10-01-09: Lecture 3
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Proteins are agents of molecular specificity! R – group (20 different side chains) – There is an R-group to transact any chemical reactions!!! Need a positive charge
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Lect-3-SV - 10-01-09: Lecture 3 Proteins (polypeptides)...

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