PP10 Water soluble Vitamins SP09

PP10 Water soluble Vitamins SP09 - Water-soluble Vitamins...

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Water-soluble Vitamins Vitamins B *Thiamin *Riboflavin *Niacin Panthothenic Acid Biotin *Vitamin B-6 *Folate *Vitamin B-12 Choline? Vitamin C
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General Properties General characteristics Dissolve in water Readily excreted In the diet Subject to cooking losses If consumed in coenzyme form, cleaved during digestion, absorbed as free vitamins 50 – 90% B vitamins in diet are absorbed Once absorbed, coenzyme forms are resynthesized Functions in body Coenzymes – necessary for enzyme activity Participate in energy metabolism
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Figure 10.11
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B Vitamin functions Energy metabolism: Thiamin - TPP Riboflavin - FMN, FAD Niacin - NAD, NADP Biotin Pantothenic acid B-12 (fatty acid breakdown)
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Figure 10.1
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Figure 10.2
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B Vitamin functions Protein metabolism: B-6 - PLP and aa metabolism Cell division: Folate B-12 Homocysteine metabolism: B-12 B-6 Folate
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B Vitamin functions Neurotransmitter production: Thiamin B-6 Vit C Myelin sheath production: B-6 B-12
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Enrichment and Fortification Many nutrients lost through milling process of grains Grain/cereal products are enriched Thiamin, riboflavin, niacin, folate, iron Whole grains contain original nutrients Enriched grains still deficient in B-6, magnesium and zinc
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Food sources of vitamins- not just the usual Thiamin – pork Riboflavin – milk – vegans? Yellow urine Niacin – Trp in proteins Folate – green leaves B-12 – No plant sources, stored in liver – vegans? Vitamin C – green leafy veggies, potatoes
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B vitamin deficiency diseases Thiamin – Beri-beri, Wernicke Korsakoff Riboflavin – Ariboflavinosis Niacin - Pellagra B-6 – Microcytic hypochromic anemia Folate – Macrocytic anemia, neural tube defects B-12 – Macrocytic anemia, pernicious anemia, parasthesia
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Thiamin functions Energy production Acetyl CoA from pyruvate, TCA cycle Neurotransmitter production acetylcholine
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Thiamin-Deficiency Disease (1) Beri-beri Occurs where polished rice is the predominant staple Poorer people cannot afford meat Peripheral neuropathy – arms and legs Onset occurs within 7 days on a thiamin deficient diet
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This note was uploaded on 10/12/2009 for the course BIBC BIBC120 taught by Professor Chilukuri during the Spring '08 term at UCSD.

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PP10 Water soluble Vitamins SP09 - Water-soluble Vitamins...

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