Routine_UA_Chemical

Routine_UA_Chemical - REAGENT STRIPS Storage Protect from...

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REAGENT STRIPS Storage Protect from moisture and excessive heat. Store at room temp. Do not refrigerate. Keep container tightly capped. Do not remove desiccant from container. Do not use beyond expiration date. Handling Review manufacturer’s instructions with each new lot number Remove strips from bottle for immediate use. Recap. Check for discoloration. Keep away from bleach, acids, fumes, etc.
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REAGENT STRIPS (continued) Testing within 30 minutes to 2 hours fresh, well-mixed, unspun at room temperature Do not touch test pad area Dip briefly, but completely - app. 1 second Drain off excess urine, avoid runover Do not lay strip on bench Compare test areas to color chart on bottle Read at specified times Know sources of error, interfering substances, sensitivity, and specificity for each strip. When automated, follow instrument’s operating manual.
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Reporting Standard terms must be used Quantitative Concentration mg/dL Plus system Qualitative Small, moderate, large Negative/positive/WRR (normal)
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pH The strip contains the indicators methyl red and bromthymol blue. The give colors over the pH range of 5-9. Colors range from orange through yellow and green to blue. Reference value on normal diet - 4.6 to 8.0
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CLINICAL SIGNIFICANCE pH Acid pH <6.0 Diet (high protein, meat, cranberries) Acidifying drugs to prevent alk. stone formation Abnormal crystalluria (bilirubin, cystine, tyrosine, leucine, cholesterol ) Uric acid stone formers Acidosis and uncontrolled Diabetes mellitus Hypokalemia Starvation
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pH (continued) Alkaline pH >6.5 Diet (vegetarian and citrus fruits) Alkaline tide produced after a meal Metabolic and respiratory alkalosis Renal tubular diseases (Fanconi’s syndrome) Alkalizing drugs to treat acid calculi formation Genitourinary tract infections pH >8.0 Contamination or old urine (not suitable for testing)
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Protein Reagent strip testing is based on the principle of protein error of the indicators. Protein in the form of albumin accepts ions from the indicator, which is buffered in a very acid medium. Color changes from shades of green to blue. Most significant for early detection of renal disease.
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CLINICAL SIGNIFICANCE PROTEIN Reference value Random urine negative (not detectable) <10mg/dL) 24 Hour <150mg or 10 mg/dL Composition Albumin, 1/3 Globulins, 2/3 Tamm-Horsfall mucoprotein (25%) Pathology >30mg/dL or on daily output Heavy >3g/day Moderate >1-3 g/day Minimal <1g/day
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CLINICAL SIGNIFICANCE PROTEIN ( CONTINUED ) Benign Functional exercise, fever, stress, exposure to cold Orthostatic positional, renal congestion Pregnancy transient, investigate cause Pathologic Prerenal: overflow of low mole weight proteins IgG light chains (Bence Jones proteins) acute phase hemoglobin, myoglobin
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Routine_UA_Chemical - REAGENT STRIPS Storage Protect from...

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