Ebola Virus Research

Both vaccines induced measurable antibody responses

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Unformatted text preview: wderJect-XR gene gun. Both vaccines induced measurable antibody responses detected by ELISA and induced cytotoxic T-cell immunity. o Another approach has been to raise neutralizing antibodies in goats or horses that are specific for the GP of Ebola. These may be useful in both vaccine design and prophylactic use. Surgical Care: • Surgical intervention generally follows a mistaken diagnosis in which Ebolaassociated abdominal signs are mistaken for a surgical abdominal emergency. Such a mistake often is fatal for the patient and for any surgical team members who become contaminated with the patient's blood. Consultations: • Whenever the diagnosis of Ebola or any other viral hemorrhagic fever is considered, the US Centers for Disease Control and Prevention, along with local and state health officials, should be contacted. • Prompt consultation with an infectious diseases physician should be made, and strict barrier isolation should be instituted. • No attempt should be made to culture the virus, except when performed in a maximum-containment biosafety level 4 laboratory with laboratory personnel wearing positive-pressure suits equipped with high-efficiency particulate air filters and an umbilical-fed air supply. Diet: • Nutrition is complicated by the patient's nausea, vomiting, and diarrhea. • Intravascular volume repletion is one of the most important supportive measures. Activity: • Recovery often requires months. Weight gain and return of strength are slow. • Ebola virus continues to be present for many weeks after resolution of the clinical illness. • Semen from men recovering from Ebola infection has been shown to contain infectious virus, and Ebola has been transmitted by sexual intercourse involving recovering men and their sex partners. o o http://www.emedicine.com/med/topic626.htm Handbook http://www.cdc.gov/ncidod/dvrd/spb/mnpages/vhfmanual/entire.pdf...
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This note was uploaded on 10/13/2009 for the course YIPH ln;ljhdfi taught by Professor Wanger during the Spring '09 term at Heriot-Watt.

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