05.04 - (pleasure VTA(reward Basolateral Amygdala(cues...

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Addiction Nucleus Accumbens and the VTA If it feels good, do it again.
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Cravings Pre-limbic releases glutamate VTA releases dopamine
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Desire **Cues** (Pavlovian) Basolateral amygdala -> desire **Stress** Hypothalamus -> stria terminus -> extended amygdala somehow to the NA leads to desires **Arousal-wakening** Orexins (hypocretins) from the lat. hypothalamus -> NA also to the VTA and back to the NA -> arousal Lust
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**Novelty** Hippocampal loop Amphetamine use increases size of medium spiny neurons of the NA
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Addiction is a learned behaviour Cerebellum: learning motor control pairing motor intent with proprioceptive info and sensory input. Basal ganglia: repetitive motor control Reticular Formation: fne motor control Hippocampus: learning declarative memories pairing sensory information with emotional state Nucleus Accumbens: cravings/pleasure centres Amygdala: perception o± ±ear Hypothalamus: stress state involving the limbic system Nucleus Accumbens Memory Prelimbic Cortex
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Unformatted text preview: (pleasure) VTA (reward) Basolateral Amygdala (cues) Hypothalamus (low-level stress) Hippocampus (novelty) medial Pre-±rontal Cortex (executive ±unction) The paths of addiction. Orbital Frontal Cortex breaks the loop. GABA glutamate dopamine VP ventral pallidus mPFC medial pre-frontal cortex Executive function: or lack thereof GABA glutamate dopamine VP ventral pallidus NA medial-dorsal thalamus medial pre-frontal cortex Basolateral Amygdala Hippocampus VTA VP Lust. .. GABA glutamate dopamine VP ventral pallidus NA medial-dorsal thalamus medial pre-frontal cortex Basolateral Amygdala Hippocampus VTA VP testosterone oxytocin norepinephrine Love! GABA glutamate dopamine VP ventral pallidus NA medial-dorsal thalamus medial pre-frontal cortex Basolateral Amygdala Hippocampus VTA VP testosterone oxytocin norepinephrine Cocaine Love testosterone norepinephrine dopamine fear glutamate on Wednesday. .....
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This note was uploaded on 10/13/2009 for the course BIO 365R taught by Professor Draper during the Spring '08 term at University of Texas.

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05.04 - (pleasure VTA(reward Basolateral Amygdala(cues...

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