Structure of DNA 11-3-08

Structure of DNA 11-3-08 - Structure of DNA I. Where is the...

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Structure of DNA I. Where is the information in DNA? a. The order f DNA II. Watson and Crick Use two sets of observationst to infer the structure of DNA a. X-ray crystallography DNA is a helix b. The amount of a base = to T base III. Subunits of Nucleic acids a. Base+ribose or deoxyribose =-nucleoside+phosphate = Nucleotide b. Pyrimidines- single ring c-t-u c. Purine- double ring- a-g d. Polymerization of DNA subunits by condenstation i. C3 and C5 carbons have an hydroxyl group ii. Link by condensation reaction (h2o released) iii. 5’-3’ links to phosphate IV. Double Helix a. Complementary base pairs stick together through H-bonds b. One goes 5-3 the opposite binding strand goes 3-5 c. C-G forms 3 bonds (h- amine) (h-bond in center) (amine hydrogen bond on bottom) d. A-t ( 2 hydrogen bonds e. The helical twists pulls the hydrophobi bases close together i. Purine and pyrimidines are flat “plate-like” perpendicular to the edges ii. Hydrophobic iii. Squeezes base pairs together and squeezes water out from them
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Structure of DNA 11-3-08 - Structure of DNA I. Where is the...

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