Synthesis of living matter 10-31-08

Synthesis of living matter 10-31-08 - Synthesis of living...

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Synthesis of living matter: The role of information I. Synthesis a. The synthesis of all the components o a cell requires > 4.000 tyhpes of proteins b. Each type of protein is unique in function c. Therefore each protein is unique in 3-dimensional structure d. Each protein is also unique in amino acid sequence e. Therefore each cell must be able to arrange amino acids into polypeptide chains in >4000 ways f. This requires instruction, gnenes II. Connecting information with dna: a. 1800’s focus on the nucleus of eukaryotic cells i. Central position ii. Uniqueness iii. Special handling of chromosomes during cell reproduction. b. Nucleus and DNA connection i. Friederich Miescher, biochemist ii. 1869 tubingen castle iii. Used pus cell nuclei to isolate “nuclein” c. Nuclein i. Acidic (- charge at cell pH) ii. Contains C,H,O,N and 10% P iii. Polymer of 4 subunits stringy material of high MW. III. Evidence that NDA stores information: Transformation a. Objective: Identify information by a fucnctional property: transformation provides the assay.
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