03-03 mcb135 apoptosis

03-03 mcb135 apoptosis - APOPTOSIS What is it? Why is it...

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APOPTOSIS What is it? Why is it important? How is it controlled? What is its role in age-related disease?
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APOPTOSIS Programmed cell death Orderly cellular self destruction Process: as crucial for survival of multi-cellular organisms as cell division MULTIPLE FORMS???
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Forms of cell death "Classic" Necrosis Apoptosis Mitotic catastrophe Passive Active Passive Pathological Physiological or Pathological pathological Swelling, lysis Condensation, Swelling, lysis cross-linking Dissipates Phagocytosed Dissipates Inflammation No inflammation Inflammation Externally induced Internally or Internally induced externally induced
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APOPTOSIS Evolutionarily conserved Occurs in all multicellular animals studies (plants too!) Stages and genes conserved from nematodes (worms) and flies to mice and humans
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STAGES OF CLASSIC APOPTOSIS Healthy cell DEATH SIGNAL (extrinsic or intrinsic) Commitment to die (reversible) EXECUTION (irreversible) Dead cell (condensed, crosslinked) ENGULFMENT (macrophages, neighboring cells) DEGRADATION
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Genetically controlled: Caenorhabditis elegans soil nematode (worm)
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This note was uploaded on 04/02/2008 for the course MCB 135k taught by Professor Timiras during the Spring '08 term at Berkeley.

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03-03 mcb135 apoptosis - APOPTOSIS What is it? Why is it...

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