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My Dog is Broken! A Case Study in Cell Signaling- AnswersAssignment 1Review Email and then write an email to Tess identifying the first messenger that starts the signal transduction in the smooth muscle cell, the likely second messenger, and finally the cellular response caused by the cell signaling cascade. Explain why the arrows go from small to bigger. Also identify whether the receptor that starts the cell signaling pathway is in the plasma membrane or intracellular. What is the first messenger that initiates the signal transduction cascade in the smooth muscle cell? What is the second messenger in the signal transduction cascade within the smooth muscle cell? Is there more than one second messenger in the signal transduction cascade initiatedby NO in the smooth muscle cell? What is the response generated by the signal transduction cascade in the smooth muscle cell? The receptor that receives the first messenger and initiates the cell signalling