Class lec ol 17 Mutations DNA repair

Class lec ol 17 Mutations DNA repair - MUTATIONS* Review...

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MUTATIONS* Review topics listed below until detection of mutants - exception SDM. We'll discuss SDM and then from Detection and isolation of mutants in class. MUTATIONS: Morphological Lethal Conditional Biochemical: auxotrophs, prototrophs Resistant How do mutations occur? Spontaneous or Induced Site – directed mutagenesis Expression of Mutations Most mutations are POINT mutations
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DETECTION AND ISOLATION OF MUTANTS Replica plating Direct selection Penicillin enrichment (reference Snyder and Champness) CARCINOGENICITY TEST (AMES TEST) DNA REPAIR Download handout from Snustad and Simmons on DNA repair Mechanisms (other than proof reading) Excision repair (General repair) Nucleotide excision a) UvrA, B, C b) UvrD (helicase) Base excision a) DNA glycosylases
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Class lec ol 17 Mutations DNA repair - MUTATIONS* Review...

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