Lect23 - Microbes respond to stimuli (by regulation) 1)...

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Microbes respond to stimuli (by regulation)
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Learning Goals 1) Students will understand that microbes need to respond to stimuli in order to adapt. a) Students will understand the basis for gene expression. b) Students will understand that regulation is always occurring in the cell and the cell changes its internal mixture of proteins based upon environmental conditions. 2) Students will be able to identify the various types of regulation in the cell, where it is applied and what types of proteins are involved in activating or repressing it. a) Students will know that a cell can respond by changing the level of transcription of a gene or genes. i) Students will know that genes that perform a common metabolic function will often (but not always) be found on contiguous pieces of DNA in prokaryotes called operons. ii) Students will understand negative regulation, which is often mediated by proteins (and RNA??) that bind to DNA and stop transcription. Such proteins are called repressors. iii) Students will understand positive regulation, which is often mediated by proteins (and RNA??) that bind to DNA and increase transcription. Such proteins are called activators. b) Students will understand attenuation as a regulatory mechanism in prokaryotes. 3) Students will be able to apply the above general concepts to the specific examples of the lactose and tryptophan operons.
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Rationale for regulation Static system: deal with what you can OR Flexible system: be prepared and able to change Name of the game: Sense a need (or an opportunity) and change behavior to respond to it.
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A mRN A Protein transcription translati
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Lect23 - Microbes respond to stimuli (by regulation) 1)...

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