Lect24 - Regulation of activity Learning Goals Students...

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Regulation of activity
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Learning Goals Students will be exposed to specific examples of regulation and be able to pick out the various types of regulation that are taking place, positive regulation, negative regulation, repression, induction, activation, feedback inhibition, enzyme modification Students will learn common regulatory circuits used by many microbes; two- component regulatory systems. sigma factors, transcriptional activators, transcriptional repressors and quorum -sensing.
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DN A mRN A Protein transcription translati active protein 1 2 3 Where should regulation occur? Speed? Cost? ulus changed “behavior” regulation
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Regulatory proteins have two states: Can bind ON OFF or Can’t bind Is this really the way it is? consider an activator…
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Equilibrium in regulatory systems : most can’t bind high concentration of effector most can bind low concentration of effector
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Attenuation in action high trp low expression low trp high expression
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Click to edit Master subtitle style Other post- mRNA stability Translation: rate of protein synthesis ( codon usage) strength of ribosome binding site.
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  Feedback inhibition Method of regulating many biosynthetic pathways Final product of pathway inhibits first
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This note was uploaded on 10/18/2009 for the course MICROBIO 303 taught by Professor Kaspar/escalnte/downs during the Spring '09 term at Wisconsin.

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Lect24 - Regulation of activity Learning Goals Students...

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