symbiosis to disease 09 (two lectures)

symbiosis to disease 09 (two lectures) - Pathogens 1 2 3 4...

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Click to edit Master subtitle style Symbiosis to disease- Important 
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Common Steps in Infections 1. Encounter (contact) 2. Entry (portals) 3. Establish Infection (colonization) 4. Cause Damage (clinical manifestations)
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Evolution n Why is it advantageous for a microbe to  harm or kill its host?
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Symbiosis to disease n Why would it be advantageous for a soil  microbe, that rarely comes in contact  with a human, to retain virulence  factors? n Why are only some strains of a species  pathogenic? 
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Infection vs intoxication
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Epidemiology n Study of factors affecting the illness and  health of populations n Evidence-based science to identify risk  factors for disease and determining optimal  treatment approaches to clinical practice n Epidemiologists investigate outbreaks, design  studies to evaluate possible linkages between  factors and health, and develop/apply 
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As of October 6, 2006, Friday, 199 persons infected with the outbreak strain of E. coli O157:H7 have been reported to CDC from 26 states. Among the ill persons, 102 (51%) were hospitalized and 31 (16%) developed a type of kidney failure called hemolytic-uremic syndrome (HUS). One hundred forty-one (71%) were female and 22 (11%) were children under 5 years old. The proportion of persons who developed HUS was 29% in children (<18 years old), 8% in persons 18 to 59 years old, and 14% in persons 60 years old or older. Among ill persons who provided the date when their illnesses began, 80% became ill between August 19 and September 5. The peak time when illnesses began was August 30 to September 1 -- 31% of persons with the outbreak strain became ill on one of those 3 days. E. coli O157 was isolated from 13 packages of spinach supplied by patients living in 10 states. Eleven of the packages had lot codes consistent with a single manufacturing facility on a particular day. Two packages did not have lot codes available but had the same brand name as the other packages. The “DNA fingerprints” of all 13 of these E. coli match that of the outbreak strain. E. coli  O157:H7 Outbreak from Fresh Spinach  Update on Multi-State Outbreak of E. coli O157:H7 Infections from Fresh Spinach, October 6, 2006 http://www.cdc.gov/foodborne/ecolispinach/100606.htm
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E. coli  O157:H7 Outbreak Case Counts by State (As of October 6, 2006) 1-4 5-9 10-14 15 or higher http://www.cdc.gov/foodborne/ecolispinach/case_count_us_map.htm E. coli  O157:H7 Outbreak from Fresh Spinach 
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Pathogenic  Escherichia coli
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Enterohemorrhagic  E. coli n Strains associated with hemorrhagic  colitis that produce Shiga-like toxins  and attaching and effacing lesions and  possess a 50-70 Mda plasmid n Median incubation period of 4 days n Low infectious dose, 10-100 cells
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This note was uploaded on 10/19/2009 for the course MICROBIO 303 taught by Professor Kaspar/escalnte/downs during the Spring '09 term at University of Wisconsin.

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symbiosis to disease 09 (two lectures) - Pathogens 1 2 3 4...

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