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Unformatted text preview: Zoology 470 - Quiz #2 – 2009 – Key (answers in bold)
This quiz has 8 questions on 2 pages, and is worth a total of 8 points, and is designed to take 10 minutes. It is designed to test basic knowledge about signaling networks important in developmental biology. Use the accompanying answer sheet and a #2 pencil to enter your answers for the following multiple-choice questions. There is one right answer for each question. Please make sure you enter your student ID number on the answer sheet. 1. Which of the following pathways relies on elevation of β−catenin to transduce its signals? a. Receptor tyrosine kinase signaling b. Wnt signaling c. Hedgehog signaling d. Receptor serine/threonine kinase such as TGF-β family receptors e. G protein-linked receptors 2. Which of the following is released into the cytoplasm as a response to elevation of inositol trisphosphate (IP3)? a. Diacylglycerol (DAG) b. Calcium ions c. Cubitus interruptus (Ci) protein d. Smads e. None of the above 3. Cells respond to Wnt signaling using which type of receptor? a. Frizzled b. Smoothened c. FGF receptor d. Steroid hormone receptor e. none of the above 4. Gli3 is a vertebrate protein related to the cubitus interruptus (Ci) protein from flies. It acts as a transcriptional repressor in cells that have not received a certain type of signal. When cells receive the signal, Gli3 becomes a transcriptional activator (i.e., it turns "on" the expression of genes). What signal is involved? a. Wnt b. Testosterone c. Hedgehog d. Notch e. fibroblast growth factor (FGF) 5. The Planar Cell Polarity (PCP) pathway is activated by what type of signal? a. Hedgehog b. BMP c. Wnt d. Steroid hormone e. None of the above Zoo 470 Quiz 2 2009 - Page 2 6. Which of the following is NOT usually true for growth factors? a. They act at short range b. Different cells respond differently to the same growth factor c. They can stimulate differentiation d. They are carried long distances in the bloodstream e. They are proteins 7. BMPs and other TGF-β family growth factors function by activating which of the following? a. Ras b. Smads c. Tcf/Lef proteins d. β-catenin e. None of the above 8. Which organelle serves as a main storage site for calcium ions? a. Lysosomes b. Ribosomes c. Phagosomes d. Apoptosomes e. Endoplasmic reticulum ...
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- Spring '08